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70 S Ribosomes Bind to Shine–Dalgarno Sequences without Required Dissociations
Author(s) -
Takahashi Shuntaro,
Akita Ryoko,
Matsuno Hisao,
Furusawa Hiroyuki,
Shimizu Yoshihiro,
Ueda Takuya,
Okahata Yoshio
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700679
Subject(s) - shine dalgarno sequence , ribosome , dissociation (chemistry) , protein subunit , messenger rna , translation (biology) , 30s , initiation factor , chemistry , eukaryotic translation , protein biosynthesis , biology , microbiology and biotechnology , biophysics , biochemistry , rna , gene
To dissociate or not to dissociate . Although it is thought that the intact 70S ribosome must dissociate into 30S and 50S subunit and the dissociated 30S subunit binds to a Shine–Dalgarno (SD) sequence of mRNA in the first step of the initiation translation, we found an additional pathway that the intact 70S ribosome can bind directly to mRNA SD sequences without a required dissociation.