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Ligand‐Stabilized Hairpin Structures Interfere with Elongation of Human Telomere
Author(s) -
Hagihara Masaki,
Goto Yuki,
Nakatani Kazuhiko
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700667
Subject(s) - telomere , tetramer , computational biology , g quadruplex , polymerase , dna , ligand (biochemistry) , biology , chemistry , biophysics , genetics , microbiology and biotechnology , nanotechnology , biochemistry , enzyme , materials science , receptor
No way ! Naphthyridine tetramer ( NT ) can bind to G–G mismatches produced by the pairing of two GGG units in hairpin secondary structures, which are a possible intermediate in the folding of telomeres into G quadruplexes. Here we report that NT ‐stabilized hairpin structures in the telomere can interfere with DNA synthesis by Taq DNA polymerase (see figure). With its unique sequence preference, NT could be used to gain deeper insight into the biological consequence of ligand–telomere interactions.