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Acyl‐Carrier Protein–Phosphopantetheinyltransferase Partnerships in Fungal Fatty Acid Synthases
Author(s) -
Crawford Jason M.,
Vagstad Anna L.,
Ehrlich Kenneth C.,
Udwary Daniel W.,
Townsend Craig A.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700659
Subject(s) - biochemistry , fatty acid , biosynthesis , fatty acid synthase , aflatoxin , biology , in vitro , enzyme , food science
Fungal fatty acids : The synthesis of fatty acids is an essential primary metabolic process for energy storage and cellular structural integrity. Fungal fatty acid synthases (FASs) are unusual among FASs and self‐pantetheinylate to their active holo ‐form. Dissection of the FAS α‐subunit involved in aflatoxin biosynthesis and in vitro assays with purified proteins revealed the activation partnerships in the aflatoxin biosynthetic pathway.