Self‐Cleavable Bioluminogenic Luciferin Phosphates as Alkaline Phosphatase Reporters | Zendy

Zhou Wenhui | Zendy; Andrews Christine | Zendy; Liu Jianquan | Zendy; Shultz John W. | Zendy; Valley Michael P. | Zendy; Cali Jim J. | Zendy; Hawkins Erika M. | Zendy; Klaubert Dieter H. | Zendy; Bulleit Robert F. | Zendy; Wood Keith V. | Zendy

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Self‐Cleavable Bioluminogenic Luciferin Phosphates as Alkaline Phosphatase Reporters

Author(s) -

Zhou Wenhui,

Andrews Christine,

Liu Jianquan,

Shultz John W.,

Valley Michael P.,

Cali Jim J.,

Hawkins Erika M.,

Klaubert Dieter H.,

Bulleit Robert F.,

Wood Keith V.

Publication year - 2008

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200700644

Subject(s) - alkaline phosphatase , luciferin , homogeneous , chemistry , phosphate , enzyme , phosphatase , biochemistry , immunoassay , chromatography , luciferase , biology , transfection , physics , antibody , immunology , gene , thermodynamics

After glow . Reactive chemical adaptors were used to stabilize bioluminogenic phosphates for monitoring alkaline phosphatase (AP) activity (see scheme). The 1,6‐elimination based luciferin phosphate exhibited ultrasensitive ability to detect ∼10 −22 mol of AP enzyme in a homogeneous solution, and picograms of protein in an immunoassay.

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