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A Molecular Basis for Damage Recognition in Eukaryotic Nucleotide Excision Repair
Author(s) -
Schärer Orlando D.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700619
Subject(s) - nucleotide excision repair , nucleotide , dna , dna damage , dna repair , lesion , triple helix , biology , genetics , computational biology , chemistry , gene , medicine , pathology
How to spot a lesion . A recent report from Min and Pavletich provides a molecular basis for how a variety of structurally diverse lesions are recognized in eukaryotic nucleotide excision repair. The initial damage sensor XPC/HR23B probes the DNA helix for thermodynamically destabilized sites and interacts with undamaged nucleotides opposite a DNA lesion.
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