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Rapid Identification of a Protein Binding Partner for the Marine Natural Product Kahalalide F by Using Reverse Chemical Proteomics
Author(s) -
Piggott Andrew M.,
Karuso Peter
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700608
Subject(s) - natural product , proteomics , chemical biology , computational biology , phage display , identification (biology) , drug discovery , small molecule , chemistry , biology , biochemistry , gene , ecology , peptide
Capable chemists : Chemists are playing an ever more important role in biology through the application of small molecules to biological systems. In this paper, we combine affinity chromatography and phage display (reverse chemical proteomics), to isolate a cellular receptor for the new anticancer drug and marine natural product, kahalalide F. The results challenge biologists to uncover the significance of the interaction between the drug and its target protein.