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A Peptide Dendrimer Model for Vitamin B 12 Transport Proteins
Author(s) -
Sommer Peter,
Uhlich Nicolas A.,
Reymond JeanLouis,
Darbre Tamis
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700606
Subject(s) - dendrimer , peptide , chemistry , amino acid , cysteine , histidine , vitamin b12 , cobalamin , molecular recognition , biochemistry , combinatorial chemistry , stereochemistry , molecule , organic chemistry , enzyme
Dendritic cobalamin ligands : The first dendritic ligands for vitamin B 12 were identified from a combinatorial library of peptide dendrimers that feature metal‐coordinating residues at the core. Molecular recognition and discrimination among different amino acid sequences revealed dendrimers with a polyanionic shell of glutamates and a coordinating cysteine or histidine at the core that displays favorable binding towards aquocobalamin.