Scalable and Concise Synthesis of Dichlorofluorescein Derivatives Displaying Tissue Permeation in Live Zebrafish Embryos | Zendy

Koide Kazunori | Zendy; Song Fengling | Zendy; de Groh Eric D. | Zendy; Garner Amanda L. | Zendy; Mitchell Valerie D. | Zendy; Davidson Lance A. | Zendy; Hukriede Neil A. | Zendy

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Scalable and Concise Synthesis of Dichlorofluorescein Derivatives Displaying Tissue Permeation in Live Zebrafish Embryos

Author(s) -

Koide Kazunori,

Song Fengling,

de Groh Eric D.,

Garner Amanda L.,

Mitchell Valerie D.,

Davidson Lance A.,

Hukriede Neil A.

Publication year - 2008

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200700565

Subject(s) - zebrafish , dichlorofluorescein , fluorescein , chemistry , scalability , combinatorial chemistry , permeation , fluorescence , computational biology , computer science , biochemistry , biology , gene , database , physics , membrane , quantum mechanics , intracellular

Don't be so negative . We have synthesized new dichlorofluorescein derivatives that are less negatively charged than fluorescein. The synthesis is concise and scalable, and the compounds are conjugation‐ready. In addition, these compounds permeate zebrafish embryos; this suggests that they might be useful fluorescent probes for bioimaging.

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