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Scalable and Concise Synthesis of Dichlorofluorescein Derivatives Displaying Tissue Permeation in Live Zebrafish Embryos
Author(s) -
Koide Kazunori,
Song Fengling,
de Groh Eric D.,
Garner Amanda L.,
Mitchell Valerie D.,
Davidson Lance A.,
Hukriede Neil A.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700565
Subject(s) - zebrafish , dichlorofluorescein , fluorescein , chemistry , scalability , combinatorial chemistry , permeation , fluorescence , computational biology , computer science , biochemistry , biology , gene , database , physics , membrane , quantum mechanics , intracellular
Don't be so negative . We have synthesized new dichlorofluorescein derivatives that are less negatively charged than fluorescein. The synthesis is concise and scalable, and the compounds are conjugation‐ready. In addition, these compounds permeate zebrafish embryos; this suggests that they might be useful fluorescent probes for bioimaging.