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Surface Modification of Tobacco Mosaic Virus with “Click” Chemistry
Author(s) -
Bruckman Michael A.,
Kaur Gagandeep,
Lee L. Andrew,
Xie Fang,
Sepulveda Jennifer,
Breitenkamp Rebecca,
Zhang Xiongfei,
Joralemon Maisie,
Russell Thomas P.,
Emrick Todd,
Wang Qian
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700559
Subject(s) - click chemistry , bioconjugation , tobacco mosaic virus , cycloaddition , conjugate , chemistry , combinatorial chemistry , cowpea mosaic virus , surface modification , virus , plant virus , organic chemistry , catalysis , virology , biology , mathematical analysis , mathematics
Click conjugation of tobacco mosaic virus : As a prototype of “click” chemistry, the Cu I catalyzed azide‐alkyne cycloaddition reaction in combination with diazonium‐coupling proved to be an efficient, versatile, and benign method to conjugate a wide range of compounds to phenolic groups of protein tyrosines. In particular, plant virus tobacco mosaic virus was chosen as a multivalent protein scaffold to demonstrate this bioconjugation strategy.