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The Human Histone Acetyltransferase P/CAF is a Promiscuous Histone Propionyltransferase
Author(s) -
Leemhuis Hans,
Packman Len C.,
Nightingale Karl P.,
Hollfelder Florian
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700556
Subject(s) - histone acetyltransferase , histone , acetyltransferase , acetylation , chemistry , biochemistry , histone methyltransferase , microbiology and biotechnology , biology , dna , gene
Catalytic promiscuity : The human histone acetyltransferase P/CAF can confer propionyl instead of acetyl marks onto peptides that mimic the H3 histone tail. Catalysis of propionyl transfer occurs with a k cat of 8.8 min −1 (versus a k cat of 12 min −1 observed for the transfer of an acetyl group) and with identical specificity for individual lysine residues in the H3 sequence.