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“Click” Xylosides Initiate Glycosaminoglycan Biosynthesis in a Mammalian Cell Line
Author(s) -
Kuberan Balagurunathan,
Ethirajan Manivannan,
Victor Xylophone V.,
Tran Vy,
Nguyen Khiem,
Do Anh
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700494
Subject(s) - glycosaminoglycan , biosynthesis , aglycone , biochemistry , chemistry , cell culture , microbiology and biotechnology , biology , stereochemistry , genetics , enzyme , glycoside
A good GAG . In order to modulate glycosaminoglycan (GAG) biosynthesis, and determine their physiological and developmental role in a spatiotemporal manner, we synthesized a library of “click” xylosides with various aglycone moieties that are very stable under physiological conditions. The synthesized compounds were examined for their ability to stimulate GAG chains in a cell line that is defective in the production of GAG chains.