“Click” Xylosides Initiate Glycosaminoglycan Biosynthesis in a Mammalian Cell Line | Zendy

Kuberan Balagurunathan | Zendy; Ethirajan Manivannan | Zendy; Victor Xylophone V. | Zendy; Tran Vy | Zendy; Nguyen Khiem | Zendy; Do Anh | Zendy

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“Click” Xylosides Initiate Glycosaminoglycan Biosynthesis in a Mammalian Cell Line

Author(s) -

Kuberan Balagurunathan,

Ethirajan Manivannan,

Victor Xylophone V.,

Tran Vy,

Nguyen Khiem,

Do Anh

Publication year - 2008

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200700494

Subject(s) - glycosaminoglycan , biosynthesis , aglycone , biochemistry , chemistry , cell culture , microbiology and biotechnology , biology , stereochemistry , genetics , enzyme , glycoside

A good GAG . In order to modulate glycosaminoglycan (GAG) biosynthesis, and determine their physiological and developmental role in a spatiotemporal manner, we synthesized a library of “click” xylosides with various aglycone moieties that are very stable under physiological conditions. The synthesized compounds were examined for their ability to stimulate GAG chains in a cell line that is defective in the production of GAG chains.

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