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Synthesis of a Stimulus‐Responsive Processing Device and Its Application to a Nucleocytoplasmic Shuttle Peptide
Author(s) -
Shigenaga Akira,
Tsuji Daisuke,
Nishioka Naomi,
Tsuda Shugo,
Itoh Kohji,
Otaka Akira
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700442
Subject(s) - stimulus (psychology) , nuclear localization sequence , peptide , chemistry , information processing , fluorophore , biophysics , computer science , microbiology and biotechnology , neuroscience , biochemistry , biology , psychology , physics , fluorescence , quantum mechanics , cytoplasm , psychotherapist
Stimulus and response . Stimulus‐responsive processing (peptide bond cleavage) devices were developed. The processing reaction was triggered by stimulus‐induced removal of a PG, and the processing products were obtained in good purity. A photo‐responsive processing device was successfully applied to develop a nucleocytoplasmic shuttle peptide. (F: fluorophore, NES: nuclear export signal. NLS: nuclear localization signal. PG: stimulus‐responsive protective group)