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Allosteric Control of Ribozyme Catalysis by Using DNA Constraints
Author(s) -
Zelin Elena,
Silverman Scott K.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700437
Subject(s) - ribozyme , allosteric regulation , hammerhead ribozyme , dna , rna , chemistry , constraint (computer aided design) , catalysis , enzyme , biochemistry , gene , mathematics , geometry
Strings attached . Covalent attachment of two DNA strands to RNA enabled allosteric control of hammerhead ribozyme catalysis by formation of a double‐stranded DNA constraint, as illustrated in the figure. The constraint acted by disrupting RNA tertiary structure while leaving the secondary structure essentially intact.