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Chemoselective Labeling of Engineered Fucosylated Glycoproteins
Author(s) -
Hackenberger Christian P. R.,
Hinderlich Stephan
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700417
Subject(s) - fucose , glycoprotein , context (archaeology) , chemistry , oligosaccharide , biochemistry , protein engineering , computational biology , biology , enzyme , paleontology
O fucose, where art thou? Metabolic oligosaccharide engineering in combination with chemoselective conjugation of biophysical labels has enabled researchers to selectively target and visualize fucose residues in cellular glycoprotein systems. These recent studies advance the chemical reporter strategy for the functional analysis of this important protein modification in a proteomic context.