A Small‐Molecule Antagonist of the Hedgehog Signaling Pathway | Zendy

Lee Jongkook | Zendy; Wu Xu | Zendy; Pasca di Magliano Marina | Zendy; Peters Eric C. | Zendy; Wang Yan | Zendy; Hong Jiyong | Zendy; Hebrok Metthias | Zendy; Ding Sheng | Zendy; Cho Charles Y. | Zendy; Schultz Peter G. | Zendy

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A Small‐Molecule Antagonist of the Hedgehog Signaling Pathway

Author(s) -

Lee Jongkook,

Wu Xu,

Pasca di Magliano Marina,

Peters Eric C.,

Wang Yan,

Hong Jiyong,

Hebrok Metthias,

Ding Sheng,

Cho Charles Y.,

Schultz Peter G.

Publication year - 2007

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200700403

Subject(s) - hedgehog , hedgehog signaling pathway , shadow (psychology) , antagonist , signalling , small molecule , cell signaling , biology , computational biology , microbiology and biotechnology , signal transduction , chemistry , computer science , biochemistry , receptor , psychology , psychotherapist

Shadow the Hedgehog . JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell‐based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK184 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.

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