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A Small‐Molecule Antagonist of the Hedgehog Signaling Pathway
Author(s) -
Lee Jongkook,
Wu Xu,
Pasca di Magliano Marina,
Peters Eric C.,
Wang Yan,
Hong Jiyong,
Hebrok Metthias,
Ding Sheng,
Cho Charles Y.,
Schultz Peter G.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700403
Subject(s) - hedgehog , hedgehog signaling pathway , shadow (psychology) , antagonist , signalling , small molecule , cell signaling , biology , computational biology , microbiology and biotechnology , signal transduction , chemistry , computer science , biochemistry , receptor , psychology , psychotherapist
Shadow the Hedgehog . JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell‐based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK184 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.