Antiplasmodial and Prehemolytic Activities of α‐Peptide–β‐Peptoid Chimeras | Zendy

Vedel Line | Zendy; Bonke Gitte | Zendy; Foged Camilla | Zendy; Ziegler Hanne | Zendy; Franzyk Henrik | Zendy; Jaroszewski Jerzy W. | Zendy; Olsen Christian A. | Zendy

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Antiplasmodial and Prehemolytic Activities of α‐Peptide–β‐Peptoid Chimeras

Author(s) -

Vedel Line,

Bonke Gitte,

Foged Camilla,

Ziegler Hanne,

Franzyk Henrik,

Jaroszewski Jerzy W.,

Olsen Christian A.

Publication year - 2007

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200700385

Subject(s) - peptoid , peptidomimetic , plasmodium falciparum , peptide , chimera (genetics) , in vitro , chemistry , ic50 , malaria , stereochemistry , combinatorial chemistry , biochemistry , biology , immunology , gene

Killing them softly . The in vitro elimination of malaria parasites with biomimetic oligomers is described. Antiplasmodial activity and varying hemolytic and prehemolytic effects were observed with a α‐peptide–β‐peptoid chimera that selectively perturbed Plasmodium falciparum ‐infected red blood cells (IC 50 21 μ m; see figure). The fact that structural variations can result in different profiles of antiplasmodial versus hemolytic/prehemolytic effects opens new possibilities in peptidomimetic research.

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