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Antiplasmodial and Prehemolytic Activities of α‐Peptide–β‐Peptoid Chimeras
Author(s) -
Vedel Line,
Bonke Gitte,
Foged Camilla,
Ziegler Hanne,
Franzyk Henrik,
Jaroszewski Jerzy W.,
Olsen Christian A.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700385
Subject(s) - peptoid , peptidomimetic , plasmodium falciparum , peptide , chimera (genetics) , in vitro , chemistry , ic50 , malaria , stereochemistry , combinatorial chemistry , biochemistry , biology , immunology , gene
Killing them softly . The in vitro elimination of malaria parasites with biomimetic oligomers is described. Antiplasmodial activity and varying hemolytic and prehemolytic effects were observed with a α‐peptide–β‐peptoid chimera that selectively perturbed Plasmodium falciparum ‐infected red blood cells (IC 50 21 μ m; see figure). The fact that structural variations can result in different profiles of antiplasmodial versus hemolytic/prehemolytic effects opens new possibilities in peptidomimetic research.