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Product‐Regulation Mechanisms for Fatty Acid Biosynthesis Catalyzed by Mycobacterium smegmatis FAS I
Author(s) -
Papaioannou Nikolaos,
Cheon HwanSung,
Lian Yiqian,
Kishi Yoshito
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700380
Subject(s) - mycobacterium smegmatis , biosynthesis , palmitic acid , chemistry , biochemistry , fatty acid , catalysis , polysaccharide , enzyme , mycobacterium tuberculosis , medicine , tuberculosis , pathology
One way or another . New mechanisms are presented to explain the bimodal product distribution in fatty acid biosynthesis catalyzed by Mycobacterium smegmatis FAS I. The predominant formation of palmitic acid and tetracosanoic acid in the presence or absence of the endogenous polysaccharides is due to the removal of the end product by a stoichiometric complex formation with the polysaccharides (indicated in red in the scheme) or by the formation of a stable self aggregate (in blue).