In Vitro Synthesis of New Enniatins: Probing the α‐ D ‐Hydroxy Carboxylic Acid Binding Pocket of the Multienzyme Enniatin Synthetase | Zendy

Feifel Sven C. | Zendy; Schmiederer Timo | Zendy; Hornbogen Till | Zendy; Berg Holger | Zendy; Süssmuth Roderich D. | Zendy; Zocher Rainer | Zendy

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In Vitro Synthesis of New Enniatins: Probing the α‐ D ‐Hydroxy Carboxylic Acid Binding Pocket of the Multienzyme Enniatin Synthetase

Author(s) -

Feifel Sven C.,

Schmiederer Timo,

Hornbogen Till,

Berg Holger,

Süssmuth Roderich D.,

Zocher Rainer

Publication year - 2007

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200700377

Subject(s) - adenylylation , substrate (aquarium) , stereochemistry , chemistry , in vitro , biochemistry , carboxylic acid , biosynthesis , combinatorial chemistry , enzyme , biology , ecology

Groping in pockets . In order to evaluate the substrate specificity of the adenylation domain of the EA module of enniatin synthetase, a set of 30 α‐ D ‐hydroxy acid derivatives with various modifications in the side chain were synthesized and tested. Due to the low substrate specificity of enniatin synthetase a number of new unnatural enniatins could be synthesised (see scheme for example).

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