Premium
How Rapidly Do Epoxides Nonspecifically Form Covalent Bonds with Thiols in Water?
Author(s) -
Albert Brian J.,
Koide Kazunori
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700365
Subject(s) - nucleophile , chemistry , epoxide , covalent bond , thiol , reactivity (psychology) , combinatorial chemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology
Rating reaction rates . Due to some concerns about the reactivity of epoxides towards the most abundant and powerful nucleophiles, thiols, in a biological setting, we report kinetic data for the consumption of five common epoxide motifs in the presence of a thiol under biologically relevant conditions.