Premium
Increasing pH Causes Faster Anion‐ and Cation‐Transport Rates through a Synthetic Ion Channel
Author(s) -
Madhavan Nandita,
Gin Mary S.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700321
Subject(s) - ion , ion transporter , ion channel , chemistry , ammonium , membrane , inorganic chemistry , nanotechnology , chemical physics , materials science , organic chemistry , biochemistry , receptor
Ion‐channel mimics are able to transmit electrical signals across phospholipid membranes, and can be envisioned as nanoswitches for molecular electronics. Here, we reported the use of pH to alter ion‐transport rates through a synthetic aminocyclodextrin ion channel. Both cation‐ and anion‐transport rates were found to increase with an increase in pH due to the unique electrostatics of the multiple ammonium groups that line the channel pore. Such pH regulation of ion transport rates is unique and can be exploited for sensing applications.