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Telomerase: A Dimeric Ménage à Trois
Author(s) -
Mergny JeanLouis,
Lacroix Laurent,
Riou JeanFrançois
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700272
Subject(s) - telomerase , biology , chemistry , stereochemistry , genetics , gene
Core components of an attractive drug target . Cohen et al. have recently demonstrated that the complex of human active telomerase, an almost universal marker for cancer, involves two copies of each of three components (hTR, hTERT and dyskerin).