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Thioglycoligase‐Based Assembly of Thiodisaccharides: Screening as β‐Galactosidase Inhibitors
Author(s) -
Kim YoungWan,
Chen HongMing,
Kim Jin Hyo,
Müllegger Johannes,
Mahuran Don,
Withers Stephen G.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700263
Subject(s) - computational biology , enzyme , chemistry , combinatorial chemistry , biochemistry , beta galactosidase , computer science , biology , escherichia coli , gene
New way of doing things . An efficient inhibitor of a human lysosomal acid β‐galactosidase was identified through screening of a small collection of thioglycosides created by using a thioglycoligase derived from a bacterial β‐galactosidase (see scheme). The results described here open the interesting possibility of finding novel and unpredicted inhibitors of enzymes of interest through the relatively simple strategy of library generation by using thioglycoligases.