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Locked Nucleic Acid–Nanoparticle Conjugates
Author(s) -
Seferos Dwight S.,
Giljohann David A.,
Rosi Nathaniel L.,
Mirkin Chad A.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700262
Subject(s) - nucleic acid , conjugate , locked nucleic acid , oligonucleotide , nanoparticle , chemistry , survivin , combinatorial chemistry , computational biology , biochemistry , nanotechnology , computer science , gene , biology , materials science , mathematics , mathematical analysis
Designer nanoparticle conjugates . Locked nucleic acid (LNA) oligonucleotides can be used to functionalize nanoparticles to yield a novel conjugate that is highly stable and has a remarkably high affinity for complementary nucleic acids. When tested in a cell line model, these conjugates were found to be effective at controlling survivin gene expression.