Locked Nucleic Acid–Nanoparticle Conjugates | Zendy

Seferos Dwight S. | Zendy; Giljohann David A. | Zendy; Rosi Nathaniel L. | Zendy; Mirkin Chad A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Locked Nucleic Acid–Nanoparticle Conjugates

Author(s) -

Seferos Dwight S.,

Giljohann David A.,

Rosi Nathaniel L.,

Mirkin Chad A.

Publication year - 2007

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200700262

Subject(s) - nucleic acid , conjugate , locked nucleic acid , oligonucleotide , nanoparticle , chemistry , survivin , combinatorial chemistry , computational biology , biochemistry , nanotechnology , computer science , gene , biology , materials science , mathematics , mathematical analysis

Designer nanoparticle conjugates . Locked nucleic acid (LNA) oligonucleotides can be used to functionalize nanoparticles to yield a novel conjugate that is highly stable and has a remarkably high affinity for complementary nucleic acids. When tested in a cell line model, these conjugates were found to be effective at controlling survivin gene expression.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research