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Carbohydrate Chain Terminators: Rational Design of Novel Carbohydrate‐Based Antifungal Agents
Author(s) -
Danac Ramona,
Ball Lucy,
Gurr Sarah J.,
Muller Thierry,
Fairbanks Antony J.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700234
Subject(s) - biochemistry , monosaccharide , glycosyltransferase , biology , oligosaccharide , enzyme , chemistry , computational biology
The terminators . A chain‐termination approach was employed to rationally design monosaccharide derivatives as inhibitors of chitin biosynthesis by replacement of the 4‐hydroxyl group of N ‐acetyl glucosamine monomers. Antifungal activity was observed for a variety of acylated monosaccharide and oxazoline derivatives by means of fungal‐spore germination and adhesion assays.