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Mutasynthesis of Geldanamycin by the Disruption of a Gene Producing Starter Unit: Generation of Structural Diversity at the Benzoquinone Ring
Author(s) -
Kim Woncheol,
Lee Jong Suk,
Lee Dongho,
Cai Xing Fu,
Shin Jin Chul,
Lee Kyeong,
Lee ChoongHwan,
Ryu Sangryeol,
Paik SangGi,
Lee Jung Joon,
Hong YoungSoo
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700196
Subject(s) - geldanamycin , benzoquinone , polyketide , ring (chemistry) , stereochemistry , scheme (mathematics) , chemistry , diversity (politics) , computational biology , gene , biology , biochemistry , biosynthesis , organic chemistry , mathematics , sociology , heat shock protein , anthropology , hsp90 , mathematical analysis
A not so familiar ring . We describe results obtained from a mutasynthetic study based on geldanamycin ( 1 ), and demonstrate that this technique can be used to extend the structural diversity of the benzoquinone ring of 1 . Our results show that geldanamycin PKS modules tolerate polyketide intermediate chains that bear unnatural benzoate components, and that they extend these structures further to produce mature polyketides (see scheme).