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Glucose‐Derived Ras Pathway Inhibitors: Evidence of Ras–Ligand Binding and Ras–GEF (Cdc25) Interaction Inhibition
Author(s) -
Airoldi Cristina,
Palmioli Alessandro,
D'Urzo Annalisa,
Colombo Sonia,
Vai Marco,
Martegani Enzo,
Peri Francesco
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700185
Subject(s) - chemistry , ligand (biochemistry) , anti apoptotic ras signalling cascade , biochemistry , cdc25 , microbiology and biotechnology , biology , signal transduction , receptor , mapk/erk pathway , cell cycle , cyclin dependent kinase 1 , cell
Too complex to change . New glucose‐derived phenylhydroxylamines inhibit nucleotide exchange on human Ras. NMR and SPR experiments indicated that the Ras–GEF interaction is inhibited when the Ras–ligand complex is formed.