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Single‐Molecule Technology for Rapid Detection of DNA Hybridization Based on Resonance Light Scattering of Gold Nanoparticles
Author(s) -
Wang Kanglin,
Qiu Xin,
Dong Chaoqing,
Ren Jicun
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700174
Subject(s) - colloidal gold , nanoparticle , oligonucleotide , resonance (particle physics) , scattering , spectroscopy , light scattering , nanotechnology , molecule , dna , chemistry , materials science , analytical chemistry (journal) , physics , optics , biochemistry , chromatography , atomic physics , quantum mechanics , organic chemistry
All that scatters … A single‐molecule detection technique, named resonance light‐scattering correlation spectroscopy, has been developed based on the extremely strong resonance light scattering of gold nanoparticles. This technology was successfully used to determine the size of gold nanoparticles, and to rapidly detect solution‐phase DNA hybridization. Complementary and single‐base mismatch oligonucleotides could be distinguished within 5 min.