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Synthesis of a Universal 5‐Nitroindole Ribonucleotide and Incorporation into RNA by a Viral RNA‐Dependent RNA Polymerase
Author(s) -
Harki Daniel A.,
Graci Jason D.,
Edathil Jocelyn P.,
Castro Christian,
Cameron Craig E.,
Peterson Blake R.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700160
Subject(s) - ribonucleotide , rna polymerase , rna , polymerase , rna dependent rna polymerase , biology , ribonucleoside , nucleoside triphosphate , rna editing , nucleotide , biochemistry , enzyme , gene
Something in the way . Nucleoside analogues that enhance the frequency of viral mutagenesis are a promising new class of antiviral agents. We report that 5‐nitroindole ribonucleoside triphosphate ( 1 ) can be universally incorporated opposite each native RNA base by the RNA‐dependent RNA polymerase (RdRP) from poliovirus, and inhibits this enzyme more potently than the triphosphate metabolite of the antiviral drug, ribavirin.