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Polyamide‐ and RNA‐Based Activators in Living Cells: A Major Step Towards Controlling Gene Expression
Author(s) -
Arndt HansDieter,
Schoof Sebastian
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700156
Subject(s) - downregulation and upregulation , peptoid , gene expression , rna silencing , rna , gene , chemistry , microbiology and biotechnology , dna , computational biology , biology , biochemistry , rna interference , peptide
Something's up! Recently, two successful approaches that lead to upregulation of gene expression in living cells have been reported. One is based on DNA‐binding polyamide–peptoid conjugates (bottom), the other on dsRNA (top). The scope and perspective of these intriguing developments are discussed.