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Disrupting Mediator with a Short Peptide Ligand
Author(s) -
Lum Jenifer K.,
Wu Zhiqian,
Mapp Anna K.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700062
Subject(s) - mediator , peptide , computational biology , chemistry , biology , microbiology and biotechnology , biochemistry
A short interruption . Although the importance of Mediator in transcriptional regulation is recognized, little is known about the protein–protein interactions in this complex. Here we report a peptide that disrupts the association of Mediator components Med14(Rgr1) and Med15(Gal11) and will be a valuable tool for elucidating the functional role of these interactions.