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Substrate Profile Analysis and ACP‐Mediated Acyl Transfer in Streptomyces coelicolor Type III Polyketide Synthases
Author(s) -
Grüschow Sabine,
Buchholz Tonia J.,
Seufert Wolfgang,
Dordick Jonathan S.,
Sherman David H.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700026
Subject(s) - streptomyces coelicolor , polyketide , polyketide synthase , streptomyces , actinorhodin , acyl carrier protein , stereochemistry , chemistry , substrate (aquarium) , biochemistry , biosynthesis , biology , computational biology , enzyme , bacteria , genetics , ecology
Protein partners . We report the biochemical characterization of two type III polyketide synthases (PKS) from Streptomyces coelicolor. Remarkably, germicidin synthase (Gcs)/SCO7221 was able to utilize both acyl‐CoA and acyl‐ACP as starter units for the production of pyrone containing compounds.