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3‐Hydroxy‐3‐Methylglutaryl‐CoA‐Like Synthases Direct the Formation of Methyl and Ethyl Side Groups in the Biosynthesis of the Antibiotic Myxovirescin A
Author(s) -
Simunovic Vesna,
Müller Rolf
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700017
Subject(s) - propionate , polyketide , biosynthesis , enzyme , atp synthase , polyketide synthase , biochemistry , chemistry , stereochemistry , side chain , organic chemistry , polymer
Deletion of taF , a homologue of 3‐hydroxy‐3‐methylglutaryl‐CoA synthase (HMGS), causes a switch in the myxovirescin programming algorithm and leads to the production of a novel myxovirescin analogue with a shorter side chain. These results provide the first in vivo evidence for the role of HMGS‐like enzymes in the incorporation of both acetate‐ and propionate‐derived units into polyketide scaffolds.