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Rational Manipulation of Carrier‐Domain Geometry in Nonribosomal Peptide Synthetases
Author(s) -
Liu Ye,
Bruner Steven D.
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700010
Subject(s) - nonribosomal peptide , peptide , rational design , enzyme , domain (mathematical analysis) , biosynthesis , chemistry , stereochemistry , biochemistry , combinatorial chemistry , biology , computational biology , genetics , mathematical analysis , mathematics
Changing the assembly line . Nonribosomal peptide synthetases are multidomain enzyme assemblies responsible for the biosynthesis of a wide range of therapeutically important natural products. Here we describe an approach to construct stable, domain‐specific conjugates of nonribosomal peptide synthetases by using synthetic analogues of coenzyme A.