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Bidirectional Control of Gold Nanoparticle Assembly by Turning On and Off DNA Hybridization with Thermally Degradable Molecular Glue
Author(s) -
Peng Tao,
Dohno Chikara,
Nakatani Kazuhiko
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700005
Subject(s) - colloidal gold , nanoparticle , nanotechnology , dna , chemistry , computational biology , materials science , biology , biochemistry
Stuck on you . A new molecular glue (TD) was found to induce hybridization at sequences that contained up to three contiguous base mismatches. The function of TD could be terminated by thermal and irreversible conversion. This thermal conversion allowed us to control DNA hybridization/denaturation. This method of turning DNA hybridization on and off was applied to controlling gold nanoparticle assembly (see figure).