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Cover Picture: The Molecular Mechanism of the Termination of Insect Diapause, Part 1: A Timer Protein, TIME‐EA4, in the Diapause Eggs of the Silkworm Bombyx mori is a Metallo‐Glycoprotein (ChemBioChem 10/2006)
Author(s) -
Isobe Minoru,
Kai Hidenori,
Kurahashi Takuya,
Suwan Sathorn,
PitchayawasinThapphasaraphong Suthasinee,
Franz Thomas,
Tani Naoki,
Higashi Kenichiro,
Nishida Hideo
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200690030
Subject(s) - diapause , bombyx mori , timer , biology , insect , period (music) , bombyx , esterase , larva , biochemistry , enzyme , botany , gene , physics , acoustics , computer science , computer hardware , microcontroller
The cover picture shows a timer protein for measuring the time interval of the termination of insect diapause. It is a computer generated 3D structure of the time‐interval‐measuring enzyme–esterase A4 (TIME‐EA4), a Cu 2 ,Zn‐SOD‐type metalloglycoprotein found in diapause eggs of the Bombyx silkworm. The particles in the rings are mixtures of colored diapause and nondiapause eggs. The latter keep growing until the black worms hatch. The diapause eggs, on the other hand, must go through a cold period (represented by the blue arrow), as in winter, before they can eventually hatch. TIME‐EA4 starts measuring the time intervals during the cold period. The article by M. Isobe et al. on p. 1590 ff describes the structure and the possible molecular mechanisms of this timer protein.