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Cover Picture: Regioselective Carbon–Carbon Bond Formation in Proteins with Palladium Catalysis; New Protein Chemistry by Organometallic Chemistry (ChemBioChem 1/2006)
Author(s) -
Kodama Koichiro,
Fukuzawa Seketsu,
Nakayama Hiroshi,
Kigawa Takanori,
Sakamoto Kensaku,
Yabuki Takashi,
Matsuda Natsuko,
Shirouzu Mikako,
Takio Koji,
Tachibana Kazuo,
Yokoyama Shigeyuki
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200690000
Subject(s) - palladium , chemistry , organometallic chemistry , aryl , catalysis , regioselectivity , carbon–carbon bond , organic synthesis , biomolecule , organic chemistry , carbon fibers , iodide , combinatorial chemistry , materials science , alkyl , biochemistry , composite number , composite material
The cover picture shows how the carbon–carbon bond formation in a protein has been achieved by a combined approach of organic synthesis and genetic engineering. Palladium‐catalyzed reactions have been used in the synthesis of a wide variety of organic molecules. Among them, the Mizoroki–Heck reaction allows alkenylation of an aryl iodide to be performed under mild conditions. In the article by S. Fukuzawa, K. Tachibana, S. Yokoyama, et al. on p. 134 ff, it is demonstrated how fragile biomolecules like proteins can be substrates for palladium‐catalyzed reactions.