The In Vitro Characterization of the Erythronolide Mycarosyltransferase EryBV and Its Utility in Macrolide Diversification | Zendy

Zhang Changsheng | Zendy; Fu Qiang | Zendy; Albermann Christoph | Zendy; Li Lingjun | Zendy; Thorson Jon S. | Zendy

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The In Vitro Characterization of the Erythronolide Mycarosyltransferase EryBV and Its Utility in Macrolide Diversification

Author(s) -

Zhang Changsheng,

Fu Qiang,

Albermann Christoph,

Li Lingjun,

Thorson Jon S.

Publication year - 2007

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200600509

Subject(s) - diversification (marketing strategy) , in vitro , glycosyltransferase , erythromycin , chemistry , stereochemistry , biochemistry , combinatorial chemistry , computational biology , biology , antibiotics , enzyme , business , marketing

By capitalizing upon the reversibility of glycosyltransferase‐catalyzed reactions, EryBV was characterized in vitro as the erythromycin mycarosyltransferase and the EryBV substrate specificity was investigated. Two‐GT (EryBV/AveBI) aglycon‐exchange reactions also led to the production of novel hybrid “erythromycin–avermectin” macrolides.

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