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The Role of Internal Water Molecules in the Structure and Function of the Rhodopsin Family of G Protein‐Coupled Receptors
Author(s) -
Pardo Leonardo,
Deupi Xavier,
Dölker Nicole,
LópezRodríguez María Luz,
Campillo Mercedes
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200600429
Subject(s) - rhodopsin , receptor , g protein coupled receptor , homology modeling , transmembrane protein , transmembrane domain , chemistry , computational biology , homology (biology) , biophysics , microbiology and biotechnology , biology , biochemistry , gene , retinal , enzyme
Not so watered down . In this review, we summarize the role of water molecules embedded in the transmembrane bundle of G protein‐coupled receptors in stabilizing intra‐ and interhelical interactions, and their use for building computer‐generated homology models.