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Efficient Enzymatic Glycosylation of Peptides and Oligosaccharides from GalNAc and UTP
Author(s) -
Bourgeaux Vanessa,
Cadène Martine,
Piller Friedrich,
Piller Véronique
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200600369
Subject(s) - glycosylation , enzyme , biochemistry , chemistry , peptide , computational biology , combinatorial chemistry , biology
One‐pot synthesis : A system has been developed to glycosylate peptides, proteins, and oligosaccharides more efficiently than conventional procedures. With the simple precursors GalNAc, UTP, and creatine‐P, four enzymes are employed in one pot to regenerate UDP‐GalNAc which is used for the transfer of GalNAc to specific acceptor substrates.