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Designing Fluorescent Sensors of Heparin
Author(s) -
Sauceda Jimena C.,
Duke Rebecca M.,
Nitz Mark
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200600361
Subject(s) - fluorophore , chloride , fluorescence , quenching (fluorescence) , chemistry , heparin , halide , ion , content (measure theory) , photochemistry , combinatorial chemistry , inorganic chemistry , biochemistry , organic chemistry , physics , optics , mathematical analysis , mathematics
When the chloride's away … A heparin sensor that increases in fluorescence intensity by 320 % upon heparin association has been designed by using a novel chloride‐dependent mechanism. This increase is due to the displacement of the quenching chloride ions from the local environment of the halide‐sensitive quinolinium fluorophore.