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Additivity of Differential Conformational Dynamics in Hyperthermophile/Mesophile Rubredoxin Chimeras as Monitored by Hydrogen Exchange
Author(s) -
LeMaster David M.,
Hernández Griselda
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200600276
Subject(s) - rubredoxin , hyperthermophile , chemistry , biophysics , crystallography , biochemistry , biology , archaea , gene
Propagation of conformational dynamics in rubredoxin is characterized by interchanging a set of residues for which the increase in the hydrogen exchange‐active local fluctuations of the hyperthermophile‐derived hybrid is faithfully mirrored by a corresponding decrease for the complementary hybrid derived from a less thermostable rubredoxin.