Stereoselectivity, Sequence Specificity and Mechanism of Action of the Azinomycin Epoxide | Zendy

DavidCordonnier MarieHélène | Zendy; CaselyHayford Maxwell | Zendy; Kouach Mostafa | Zendy; Briand Gilbert | Zendy; Patterson Laurence H. | Zendy; Bailly Christian | Zendy; Searcey Mark | Zendy

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Stereoselectivity, Sequence Specificity and Mechanism of Action of the Azinomycin Epoxide

Author(s) -

DavidCordonnier MarieHélène,

CaselyHayford Maxwell,

Kouach Mostafa,

Briand Gilbert,

Patterson Laurence H.,

Bailly Christian,

Searcey Mark

Publication year - 2006

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200600244

Subject(s) - depurination , epoxide , diastereomer , chemistry , stereoselectivity , stereochemistry , guanine , alkylation , sequence (biology) , natural product , biochemistry , dna , nucleotide , catalysis , gene

Not like the rest . In this study we show that the four diastereomers of the azinomycin epoxide ( 1 ) have different sequence selectivities, while the natural product appears to exert its effects through reversible N 7 alkylation of guanine followed by irreversible depurination (see scheme).

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