A New Class of Arylamine Oxygenases: Evidence that  p ‐Aminobenzoate  N‐ Oxygenase (AurF) is a Di‐iron Enzyme and Further Mechanistic Studies | Zendy

Simurdiak Michael | Zendy; Lee Jungkul | Zendy; Zhao Huimin | Zendy

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A New Class of Arylamine Oxygenases: Evidence that p ‐Aminobenzoate N‐ Oxygenase (AurF) is a Di‐iron Enzyme and Further Mechanistic Studies

Author(s) -

Simurdiak Michael,

Lee Jungkul,

Zhao Huimin

Publication year - 2006

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200600136

Subject(s) - oxygenase , chemistry , enzyme , stereochemistry , class (philosophy) , heme oxygenase , biochemistry , philosophy , heme , epistemology

Alternative route . The p ‐aminobenzoate N‐ oxygenase (AurF) from the aureothin biosynthetic pathway in Streptomyces thioluteus is a novel di‐iron enzyme. Rather than through the previously proposed mechanism, AurF in fact catalyzes the conversion of substrate p ‐aminobenzoate to p ‐nitrobenzoate through at least three consecutive reactions: two monooxygenation steps (a and c) and one dehydrogenation step (b).

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