Calix[6]arene‐Based Template for X‐ray Crystallographic Analysis of Template‐Assembled Synthetic Proteins | Zendy

Tsukamoto Koji | Zendy; Ohishi Hirofumi | Zendy; Maezaki Naoyoshi | Zendy; Tanaka Tetsuaki | Zendy; Ishida Toshimasa | Zendy

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Calix[6]arene‐Based Template for X‐ray Crystallographic Analysis of Template‐Assembled Synthetic Proteins

Author(s) -

Tsukamoto Koji,

Ohishi Hirofumi,

Maezaki Naoyoshi,

Tanaka Tetsuaki,

Ishida Toshimasa

Publication year - 2006

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200600132

Subject(s) - crystallinity , crystallography , bromine , peptide , chemistry , derivative (finance) , flexibility (engineering) , crystal structure , combinatorial chemistry , materials science , organic chemistry , biochemistry , statistics , mathematics , financial economics , economics

Crystal visions . We have developed a novel calix[6]arene derivative 1 as a topological template of template‐assembled synthetic proteins. In addition to its high crystallinity, the bromine‐containing template facilitated phasing in X‐ray analysis. This revealed four conformationally different structures of 1 (see figure). The X‐ray structure showed that the template adopts the desired flattened‐cone conformation, and its p ‐bromophenylalanine moieties have the suitable flexibility for introduction of various peptide chains.

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