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Water Exclusion and Enantioselectivity in Catalysis
Author(s) -
Breslow Ronald,
Bandyopadhyay Subhajit,
Levine Mindy,
Zhou Wenjun
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200600120
Subject(s) - polyethylenimine , enzyme , chemistry , catalysis , enzyme catalysis , selectivity , aqueous solution , biocatalysis , artificial enzyme , combinatorial chemistry , organic chemistry , biochemistry , reaction mechanism , transfection , gene
High and dry . Enzymes perform catalyses in the interior of the protein, which is not aqueous in character. Polyethylenimine enzyme mimics with a hydrophobic core also achieve high rates by excluding water. Two different approaches to the synthesis of such artificial enzymes with chirally attached side chains are described, as well as the use of these enzymes in performing biomimetic transaminations with chiral selectivity