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Recognition on the Nanoscale of a DNA Sequence by an Inorganic Crystal Surface
Author(s) -
Scipioni Anita,
Pisano Sabrina,
Bergia Anna,
Savino Maria,
Samorì Bruno,
De Santis Pasquale
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200600079
Subject(s) - mica , nanoscopic scale , sequence (biology) , dna , field (mathematics) , surface (topology) , nanotechnology , dna sequencing , palindrome , palindromic sequence , atomic force microscopy , crystal (programming language) , computational biology , crystallography , chemistry , computer science , biology , materials science , gene , biochemistry , mathematics , paleontology , genome , geometry , pure mathematics , programming language
Statistical analysis of the profiles of palindromic DNA molecules imaged by atomic force microscopy provided evidence of the capability of a mica surface of recognizing DNA sequences. The differential free energy involved in this collective recognition process was estimated. A tentative model based on sequence‐dependent imbalances of the electrostatic field normal to the surface ( E ) along the chain is proposed.