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A Phenol Quaternary Ammonium Porphyrin as a Potent Telomerase Inhibitor by Selective Interaction with Quadruplex DNA
Author(s) -
Wang Ping,
Ren Lige,
He Hanping,
Liang Feng,
Zhou Xiang,
Tan Zheng
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200600036
Subject(s) - porphyrin , steric effects , pyridinium , chemistry , cationic polymerization , dna , g quadruplex , phenol , ammonium , stereochemistry , combinatorial chemistry , medicinal chemistry , biochemistry , organic chemistry
Not adding anything new? Phenol quaternary ammonium derivatives have been found to cross‐link DNA efficiently. Experimental data indicate that a phenol quaternary ammonium cationic porphyrin (TQMP) potently inhibits a telomerase (IC 50 =1.7 μ M ) due to its selective, stabilizing interactions with G‐quadruplexes. These interactions might derive from the greater flexibility of TQMP over pyridinium porphyrins and its steric effect.