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Expression of Alternaria solani PKSF Generates a Set of Complex Reduced‐Type Polyketides with Different Carbon‐Lengths and Cyclization
Author(s) -
Kasahara Ken,
Fujii Isao,
Oikawa Hideaki,
Ebizuka Yutaka
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200600034
Subject(s) - alternaria solani , polyene , aspergillus oryzae , polyketide , stereochemistry , chemistry , biology , gene , biosynthesis , botany , biochemistry , enzyme , blight
An iterative type I polyketide synthase gene , named pksF , has been cloned from Alternaria solani. The Aspergillus oryzae pksF expression transformant produced two new polyene products, named aslanipyrone ( 1 ) and aslaniol ( 2 ), and at least nine other polyene compounds.
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