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Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6
Author(s) -
Chefson Amandine,
Zhao Jin,
Auclair Karine
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200600006
Subject(s) - cofactor , hydrogen peroxide , chemistry , natural product , dioxygenase , organic synthesis , cumene hydroperoxide , cumene , enzyme , stereochemistry , biochemistry , organic chemistry , combinatorial chemistry , catalysis
P450 enzymes made easier to use in synthesis . The use of cumene hydroperoxide with CYP2D6 or CYP3A4 leads to as much as a twofold increase in the rate of product formation compared to the use of the natural cofactors.