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Cover Picture: The Target Discovery Process (ChemBioChem 3/2005)
Author(s) -
Egner Ursula,
Krätzschmar Jörn,
Kreft Bertolt,
Pohlenz HansDieter,
Schneider Martin
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200590008
Subject(s) - drug discovery , cover (algebra) , identification (biology) , business process discovery , computational biology , process (computing) , computer science , small molecule , nanotechnology , biology , bioinformatics , work in process , engineering , materials science , biochemistry , operations management , botany , business process modeling , operating system , business process , mechanical engineering
The cover picture shows the target discovery process as implemented at Schering AG for work on kinases. Before a target enters the lead discovery phase, the target candidate has to pass several hurdles to maximise the likelihood of achieving target‐selective inhibition by small‐molecule inhibitors. This target‐discovery process comprises three phases: target identification, drugability assessment and functional target validation. Further details can be found in the article of U. Egner et al. on p. 468 ff.